Model Answers have developed a web-based application that enables real-time simulation to explore paediatric doses that result in exposure levels similar to adults. The adult PK information is scaled to paediatric subjects by taking into account different age groups, allometric principles, as well as age-dependent maturation (ontogeny) of user-defined elimination processes.
The application also enables users to evaluate the sample size required for a pharmacokinetic study in paediatrics by prospectively targeting adequate power to estimate clearance and volume of distribution.
Our free demo application can be accessed at the following address: https://interactive.model-a.com.au/paediatrics-demo
For questions and comments please email us directly at: firstname.lastname@example.org